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Keywords: fibromyalgia; palmitoylethanolamide; melatonin; nutraceuticals; pain; snooze; Standard of livingIdea of exogenous PEA pharmacokinetics is still at an early stage [212]. Foreseeable future investigation should assess the specific tissue distribution and web page of metabolism of PEA in order to determine correct pharmacokinetic profiles of
Of note is, as a consequence of PEA’s higher lipophilicity, micronized or ultra-micronized formulations are believed to generally be extra conveniently absorbable, with a lot more favorable pharmacokinetics and larger efficacy. Although There may be some proof supporting this principle, there remains no proof of the superiority of micronized PEA